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INBIOTitle of the Sub-Project: INBIO - Stable enzymes as industrial catalysts Description: The use of enzymes for industrial transformation processes, though generally recognized as environmentally friendly and specific, is often hampered by the high cost of biocatalysts and therefore neglected by small and medium sized companies. In this frame, stability is an important parameter, which affects the economic feasibility of applying an enzyme in an industrial process as it reduces enzyme turnover and permits the use of high process temperatures and of organic solvents. The aim of INBIO is to contribute to the diffusion of biocatalysis by a clear demonstration of specific applications. INBIO has the general objective of producing knowledge, materials and methodologies suitable to foster the diffusion of biocatalysis to regional productive activities. The following steps will be performed: i) select model reactions of industrial interest for which temperature, solvents, turnover of the catalyst are critical; ii) characterise enzymes able to carry out such reactions; iii) study the conformation of enzymes endowed with different stabilities in different reaction conditions; iv) modify a few selected catalysts by molecular techniques to improve stability INBIO contributes to the REGINS strategic goals through: - establishment of research cooperation among the participants in a field of importance for both partners. - unrestricted diffusion of results and materials among partners. - free diffusion of the results of the project. In addition, this project is supposed to provide a convincing proof of principle about the usefulness of biocatalysis for a broad range of applications and therefore will foster cooperation with companies of the participating regions. The enzymes and processes characterised and developed through the project are suitable to be exploited through joint research projects or agreements with companies. Project Partners: - University of Milano-Bicocca - Department of Biotechnology and Biosciences (I) - Johannes Kepler University Linz - Institute of Organic Chemistry (A) Contact: For further questions please contact: Ms Marina Lotti Universitā Milano-Bicocca Dip. Biotecnologie e Bioscienze Piazza della Scienza 2 20126 Milano ITALY Tel.: (+39) 02 6448 3527 Fax: (+39) 02 6448 3565 E-mail: marina.lotti@unimib.it  Project Sheet INBIO
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